

🛡️ Stay ahead of pests—because your dog deserves the best defense!
FRONTLINE Plus Flea and Tick Treatment for X-Large Dogs delivers fast-acting, waterproof protection that kills fleas, flea eggs, larvae, chewing lice, and ticks for a full 30 days. Trusted by pet owners for over two decades, its unique formula with fipronil and (S)-methoprene breaks the flea life cycle while being easy to apply and safe for dogs 8 weeks and older, weighing 89 to 132 lbs.


















| Active Ingredients | fipronil and (S)-methoprene |
| Brand | Frontline |
| Customer Reviews | 4.4 out of 5 stars 15,083 Reviews |
| Item Form | Liquid |
| Item Volume | 302.4 Milliliters |
| Item Weight | 1.6 Ounces |
| Scent | Unscented |
T**E
This stuff still works great
I bought this because I remember, this was the first thing that came out to kill fleas & ticks! I haven't seen any in years! I'm glad I found it on Amazon! Because I can't afford the other stuff & too! The other stuff I don't really trust it much! This is well worth the money, & has worked great on my 116 pound German shepherd, yup she could lose a few pounds. But she's not scratched for fleas.. she does have dry skin. There was no smell & always fell safe applying the tube opening it away from me & applying it between the shoulder's! So thankful they still make Frontline & it works! Am definitely going to be buying more!
S**H
Still works in my part of the state
Easy to apply if you can make a part in your dog's hair. I always get it on my hands and wash it off as soon as I am done with the dogs. Never a problem on my skin due to this timeliness I guess. Kills the ticks who settle down to bite and still works on fleas for me. Ten miles down the road, however, it does not work anymore. Life finds away...
R**S
There ain't no bugs on Skip or Rayne!
Works as it should! No fleas and no ticks! Easy to apply and lasts 90days with no weird smell.
K**R
Flea med
Helps but bad year and not lasting for maybe 2weeks at most on the dogs
K**J
Best flea and tick med!
Arrived quickly. Always works so well for fleas and ticks for our 2 German Shepherds (very thick hair). We live on lots of land with woods so they come into contact with fleas/ticks, but when Frontline is used, we don’t have any problems. Love the bigger pack that is offered and at the best price!! Fleas: No fleas on our dogs! Ease of application: Just takes a few seconds to apply!
A**Y
Good product
Product works well, I live in Florida, off grid, in the woods. We have lots of sand, and my lab is active and always playing in the forest. I never have problems with ticks or fleas. Nats are still a pain, but I use Avons, Skin So Soft, I spray it on my hands, lightly pass over her eyes, back and tail. I've never seen skin or eye irritation from any of my dogs. From the flea control or the Skin so soft. Hope this helps.
A**R
Wouldn’t recommend ,
I don’t know if they change the formula or what happened but for some reason it does not work anymore. We were using this every month to treat our dogs and they still had fleas. Do not recommend this at least not for tough environments like Florida.
B**D
Worked better than other flea and tick treatments
Worked better than other flea and tick treatments. Lasted longer
Trustpilot
3 weeks ago
5 days ago