How to Start an Evolution

For a Book on extending life, he ignored a very important study by a intelligent, friendly country, NORWAY. When offered a chance to buy Statins for the Norwegian population, Norway was not impressed with the American Drug Company Clinical Studies where Pfizer chose 20,000 men only, no women, and only men aged 22 to 45, no old men. The Norwegians decided to do their own Cholesterol Study. They did 4 studies named, Hunt-1, Hunt-2, Hunt-3 and Hunt-4. Norway used the entire population of 4 Norwegian cities, about 55,000 Norwegians, more than half, Women and lots of old men in the study. The results were surprising. First the Hunt-2 study says that for Women, high cholesterol is not detrimental and may be Healthy. And for old men, the study showed that Men over 60 years of age with High Cholesterol live longer than Men over 60 with Low Cholesterol. Since this is Dr. Sinclair's book on aging, I think the Norwegian studies deserve a mention. You can find the studies at NIH PubMed. I am 83 years old and refuse to take a Statin. I was diagnosed with cardiovascular disease and Severe Calcification of my 4 Arterial Arteries. My heart surgeon gave me 1 to 2 years of remaining life. I am writing this review 10 years after my Heart Stent Surgery. I searched the internet and found on the NIH PubMed site a study from Poland by researcher, Dr Katheryn Mayzek which said the reason we build artery calcium plaque is the lack of Vitamin K2 in our diet. Being the only hope of removing Calcium from blood vessels, I bought a bunch of Vitamin K2 pills on Amazon. The max pill dosage then was 100 mcg, micrograms. It takes ten of these pills to make 1mg. My brother-in-law and my golfing buddy both had blocked heart arteries and had Stents installed. I took 12, 100mcg pills per day, 4 morning, 4 afternoon and 4 evening. My two friends would only take 2 of the weak pills. After 6 months my four heart arteries were clear of all calcium plaque. My doctor could not believe it. My two friends who only took 2 of the pills each day were still severely calcified and were given open heart surgery to install bypass arteries using arteries from their legs. I was clear. THIS IS IMPORTANT. There is a test, an x-ray, Heart CT Scan called a Calcium Score that finds ALL calcium plaque in your arteries. GET ONE. A heart surgeon and a radiologist will grade your Calcium Plaque telling you if your have dangerous, deadly plaque or not. It is not the calcium plaque that kills us, the plaque covers the interior artery wall denying the artery fresh blood for nourishment and the artery wall becomes toxic with Lesions (think of BIG pimples inside the artery wall) when the Lesion is ripe (it takes years, my 9 lesions were thought to be over 10 years old) it explodes into your artery and most people drop dead or fail to wake in the morning. The Lesions are like bullets pointed at your heart. Get the Calcium Score, it is more important than a EKG which does not detect Calcium Plaque. Calcium Scores predict your chance of experiencing a Lesion explosion in the following years. EKGs can't do that. GET A CALCIUM SCORE. If you do have Calcium Plaque Vitamih K2, MK7 from NATTO will remove the Calcium Plaque, and it is not Cholesterol its Calcium. My heart surgeon said Cholesterol is the basic building bloc of the body and without cholesterol, we die. And the Norwegians and my Heart Surgeon both say there is NO BAD CHOLESTEROL, all cholesterol is good.He said he did not take Statins and said they were a danger and killed our Mitochondrial. We definitely cannot live without Mitochondrial so why take a Mitochondrial Poison?? That's crazy. Another thing, ask your Cardiologist which Statin He/She takes. I have asked a dozen and they all answered, "I am allergic to Statins, they cause severe muscle pain and I don't take Statins." No kidding, ask your cardiologist. If you don't know what Mitochondrial is or what it does, you need to buy one of the excellent books on Amazon that explains it to you.I am 83 years old. Retired Navy Pilot and Retired Airline Pilot. I take 6, 500mcg Vitamin K2 tablets I buy on EBAY from London. They cost so much less than any sold on Amazon. Compare the cost per 100mcg. The difference is HUGE. This information is intended for men and women. Get your Calcium Score. Know how clogged your arteries are. One last thing. Harpers Bazzar magazine and at least two other women's magazines and Oprah have done stories on Vitamin K2. They all say, 'Wrinkles are caused by Calcium in Soft Tissue.' Take the K2 and the wrinkles disappear so do the purple blood vessels in our legs. No kidding it works. I also lost ALL joint pain. It was Calcium in the joints. My hip pain kept me awake. Now, all joint pain is gone. And I feel 30, not 83 and plan to live to 120 playing golf and playing with my grandchildren and great grandchildren. God Bless and Good Luck. Dave Williams

This is a well written and deeply researched book written by an expert in the field, with the help of a professional writer, that focuses on research, gene therapies and supplements that are intended to extend human, and even non-human, lifespans. As such, it succeeds brilliantly as it presents a wealth of material in a concise introduction to the subject and provides an excellent review of what he and other aging researchers and geneticists have learned up to 2019.Where I think the book falls short is in more thoroughly linking the effects of diet on health and in making, even in an Appendix, specific dietary recommendations, both pro and con, and providing a more thorough basis for the reader to make informed decisions. Yes, there are many other books that do this, but they do not provide the related genetic and supplement information, so readers are required to look in multiple volumes to get a more complete view of linkages between diet, health, and longevity.The book also makes very few references to exercise although it encourages the reader to be active every day.I think that a second edition of this book could be more useful by providing the core information covered in this edition, and updates, plus specific recommendations on what to and not to eat (or specific recommendations on where to get that information) as well as what kinds of exercise are recommended for each age group (or where to get that information).The obesity epidemic so prevalent in Western countries and food insecurity issues prevalent worldwide are not mentioned, and probably ought to be. There is emphasis at the end of the book on global food waste and on consumerism, and how these affect the planet's ability to sustain increasing human populations, but these are not integrated into the overall thesis that great strides in extending human lifetimes are upon us and solutions are not offered.A very thought-provoking book and one which offers a very optimistic view of the future, but one that I think ought to be expanded to integrate diet and exercise into the theme of extending lifespan.

Dr Sinclair presents his revolutionary theory regarding aging and presents his arguments why aging should be considered a disease. This would be a monumental paradigm shift and could refocus enormous resources to fighting this disease with the consequence of extended lifespans.I liked this book because Dr Sinclair addresses all the arguments that are going through peoples heads as they read it, from it sounding like science fiction to it turning everything we’ve been taught on its head.Dr Sinclair is a professor at Harvard Medical School. Without these credentials I assume this book would be written off by most. He spends a lot of time addressing arguments that expose the underlying nihilism in our culture and death-worship that is the foundation of many current movements.Fascinating read and highly recommend. My hopes are not high but I agree with Dr Sinclair in that if he is right, this will be the largest turning point in human history!

Although the book is split into three sections - the past, the present and the future - it reads as two halves: what is essentially scientific and what is decidedly ethical. When Dr Sinclair confines himself to his subject, it very difficult to put the book down. He discusses the advances in genomics, etc, that led him and others to studying ageing, before discussing current research and the notion that ageing is more a disease than a natural process. He includes some scientific detail, a few useful analogies and a good smattering of anecdotes to impress and educate the reader, which, despite some obvious padding, he undeniably does. I think a typical scientist would and should stop right there; for science does not concern itself with morality but with pure knowledge whether constructive or destructive. Nonetheless, Dr Sinclair goes on to debate the real and political consequences of people living, if not forever, certainly much longer than they do now. To me, this is where the book rapidly goes down hill. Dr Sinclair knows there will be serious repercussions: an increase in population; a greater demand for resources; more pollution; more carbon emissions; etc, etc. He says that alongside the big increase in population in the 1800's was a huge increase in the standard of sanitation and health as though it were causative - more people lead to more benefits. He thinks that GMO and foods modified by other technologies will provide the solution to feeding the ever-increasing numbers of mouths and gets irritated when some people have the temerity to question their safety. Also, because he would be content to work doing his interesting research in his lab for the next 50 years, it does not mean a miner would like to spend another 50 digging coal. Despite Dr Sinclair's faith in the ingenuity of man, there are times when i sense he is trying to convince himself of his utopian vision rather than the reader. Living to infinity is not the be all and end all; living a healthy life is more important, whether one lives to 70 or 90. At some point I will re-read the first half of the book - which I enjoyed - but not the second. I must be only part Luddite.

Very interesting book. Destroys the paradigm that aging is natural and opens your mind to it being a disease (basically a failure in our genes.)Richard Dawkins touched on why we would inherit genes that fail as we age: essentially we reproduce before we suffer from these age-related ailments, and so natural selection has not filtered it out as it presumably has young man/woman ailments that would kill off the would-be reproducer.The book uses scientific terms and explanations and so some reading on physiology may be beneficial alongside this book. Note taking is a must if you're wanting to retain and be able to explain the contents.The reason I've given it 3 out of 5 stars is the completely lack of concern over the animals the author and his colleagues tested on. I know its commonplace (though this doesn't make it right) but there is not even any acknowledgement from the author that this is cruel behaviour. He will talk about how he'll age mice prematurely (yes fascinating but cruel), starve them, dissect them prior to natural death, etc. He does comment on how easy it is to buy mice to test on, though. Well, as long as subjecting unlucky animals to torture is convenient!

Great book. Really interesting. Gives a glimpse of the future in terms of cutting edge gene therapy but also provides advice that anyone can implement now e.g. fasting, exercise, calorie restriction and certain supplements. Highly recommended.

For someone who is not a Scientist or indeed aware of any of the issues in the book, this book is a must read if you are in the slightest bit interested in enjoying this wonderful life for as long as possible. It has certainly opened up my mind to what is possible and encourages you to look at our human bodies in a totally different way. I guess for experts a lot of the information is 'old hat' for me it proved to be the springboard to find out as much as I can about living longer and healthier. I hope to be a very well informed layman in 6 months time able to make some key decisions. Outstanding read.

I am reading this book while traveling. It is better than I expected and deeply personal from David. I already know many of the topics the book is talking about but I find it very useful to consolidate my knowlege. The knowledge in this book is of enormous value and at the same time the book is low cost. I think it is the most important book I read this year.