* Description ( #tabs-1 )
This is an over the counter product - it does not
require prescription.
Adequan I.M., 7 Vials (5 ml each)
Product Description:
For Intramuscular Use In Horses
Adequan® i.m. inhibits harmful enzymes that attack the synovial
fluid and cartilage while stimulating cartilage repair. The
health of the cartilage is critical to the performance of the
joint. Adequan® i.m is complete FDA- approved one-horse
treatment regimen per package of 7 vials.
Caution:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
Description:
Each 5 milliliters of Adequan® i.m. contains 500 mg of
Polysulfated Glycosaminoglycan and Water for Injection q.s.
Sodium Hydroxide and/or Hydrochloric Acid added when necessary to
adjust pH. Sodium Chloride may be added to adjust tonicity.
Improves carpal flexion by 71%. Improves synovial fluid protein
by 83%.
Pharmacology:
Polysulfated Glycosaminoglycan is chemically similar to the
glycosaminoglycans in articular cartilage matrix. PSGAG is a
potent proteolytic enzyme inhibitor and diminishes or reverses
the pathologic recesses of traumatic or degenerative joint
disease which result in a net loss of cartilage matrix
components. PSGAG improves joint function by reducing synovial
fluid protein levels and increasing synovial fluid Hyaluronic
acid concentration in traumatized equine carpal and hock joints.
Toxicity:
Toxicity studies were conducted in horses. Doses as high as
2,500 mg were administered intramuscularly to 6 horses twice a
week for 12 weeks. This dosage is 5 times the recommended dosage
and 3 times the recommended therapeutic regimen. Clinical
observations revealed no o redness or swelling at the injection
site or in the affected joint. No animal had any clinical or
laboratory evidence of toxicity.
Indications:
Adequan® i.m. is recommended for the intramuscular treatment of
non-infectious degenerative and/or traumatic joint dysfunction
and associated lameness of the carpal and hock joints in horses.
It stimulates the natural joint repair process within 2 hours of
the first injection.
Contraindications:
There are no known contraindications to the use of intramuscular
Polysulfated Glycosaminoglycan.
Warning:
Not for use in horses intended for food.
Dosage and Administration:
The recommended dose of Adequan® i.m. in horses is 500 mg every
4 days for 28 days intramuscularly. The injection site must be
thoroughly cleansed prior to injection. Do not mix Adequan® i.m.
with other drugs or solvents.
Reproductive Safety:
Studies have not been conducted to establish safety in breeding
horses.
Dispose of spent needles in accordance with all federal, state
and local environmental laws.
Warning:
Keep this and all medications out of the reach of children.
How Supplied:
Adequan® i.m. solution, 500 mg/5 mL is available in 5 mL glass
vials, packaged in boxes of 7.
Storage Conditions:
Store at controlled room temperature 18°-25°C (64°-77°F).
Discard unused portion.
