what does it mean "too big to use with portable" oxygen machine?

Yes, I would think so. I use mine for the home unit, when I get up I put the cannula in the cover. That said depending what you carry you portable in it might work for you

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Description

🛡️ Keep it clean, keep it classy — protect your oxygen gear in style!

COMPACT PORTABLE - Lightweight 34g and small footprint make it easy to carry and store wherever you go.
PATENTED PROTECTION - Unique design prevents nasal prongs from touching internal surfaces, maintaining cleanliness and integrity.
ECO FRIENDLY LONGEVITY - Reusable design reduces waste and extends the life of your nasal cannula—save money and the planet.
PERFECT FIT EVERY TIME - Fits all standard adult nasal cannulas up to 2.5 inches wide for universal compatibility.
HYGIENE MEETS CONVENIENCE - Dishwasher safe and easy to clean, ensuring your cannula stays fresh and ready.

The Keystone Healthcare Innovations Oxygen Nasal Cannula Protective Cover is a compact, reusable storage solution designed to fit all standard adult nasal cannulas up to 2.5 inches wide. Featuring a patented design that prevents nasal prongs from contacting internal surfaces, it ensures superior hygiene. Dishwasher safe and eco-friendly, this lightweight cover extends the lifespan of your cannula while offering convenient, on-the-go protection.